Ontology highlight
ABSTRACT:
SUBMITTER: Chen YJ
PROVIDER: S-EPMC4116146 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Chen Ying-Jr YJ Huang Xiaojing X Mahieu Nathaniel G NG Cho Kevin K Schaefer Jacob J Patti Gary J GJ
Biochemistry 20140715 29
It is well established that most cancer cells take up an increased amount of glucose relative to that taken up by normal differentiated cells. The majority of this glucose carbon is secreted from the cell as lactate. The fate of the remaining glucose carbon, however, has not been well-characterized. Here we apply a novel combination of metabolomic technologies to track uniformly labeled glucose in HeLa cancer cells. We provide a list of specific intracellular metabolites that become enriched aft ...[more]