A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect.
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ABSTRACT:
SUBMITTER: Dai Z
PROVIDER: S-EPMC5018130 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect.
Dai Ziwei Z Shestov Alexander A AA Lai Luhua L Locasale Jason W JW
Biophysical journal 20160901 5
The Warburg effect, or aerobic glycolysis, is marked by the increased metabolism of glucose to lactate in the presence of oxygen. Despite its widespread prevalence in physiology and cancer biology, the causes and consequences remain incompletely understood. Here, we show that a simple balance of interacting fluxes in glycolysis creates constraints that impose the necessary conditions for glycolytic flux to generate lactate as opposed to entering into the mitochondria. These conditions are determ ...[more]
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