Ontology highlight
ABSTRACT:
SUBMITTER: Zhu H
PROVIDER: S-EPMC4116495 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Zhu Hua H Zhang Hui H Jin Feng F Fang Mingzhu M Huang Mark M Yang Chung S CS Chen Tong T Fu Liwu L Pan Zui Z
Oncotarget 20140601 11
Effective treatment as well as prognostic biomarker for malignant esophageal squamous cell carcinoma (ESCC) is urgently needed. The present study was aimed at identifying oncogenic genes involving dysregulated intracellular Ca2+ signaling, which is known to function importantly in cellular proliferation and migration. Tumors from patients with ESCC were found to display elevated expression of Orai1, a store-operated Ca2+ entry (SOCE) channel, and the high expression of Orai1 was associated with ...[more]