Ontology highlight
ABSTRACT:
SUBMITTER: Hamada J
PROVIDER: S-EPMC4941375 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Hamada Junichi J Shoda Katsutoshi K Masuda Kiyoshi K Fujita Yuji Y Naruto Takuya T Kohmoto Tomohiro T Miyakami Yuko Y Watanabe Miki M Kudo Yasusei Y Fujiwara Hitoshi H Ichikawa Daisuke D Otsuji Eigo E Imoto Issei I
Oncotarget 20160301 13
T-cell intracellular antigen-1 (TIA1) is an RNA-binding protein involved in many regulatory aspects of mRNA metabolism. Here, we report previously unknown tumor-promoting activity of TIA1, which seems to be associated with its isoform-specific molecular distribution and regulation of a set of cancer-related transcripts, in esophageal squamous cell carcinoma (ESCC). Immunohistochemical overexpression of TIA1 ectopically localized in the cytoplasm of tumor cells was an independent prognosticator f ...[more]