Ontology highlight
ABSTRACT:
SUBMITTER: Ghobadloo SM
PROVIDER: S-EPMC4116624 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Ghobadloo Shahrokh M SM Balcerzak Anna K AK Gargaun Ana A Muharemagic Darija D Mironov Gleb G GG Capicciotti Chantelle J CJ Briard Jennie G JG Ben Robert N RN Berezovski Maxim V MV
Scientific reports 20140731
The inability of vaccines to retain sufficient thermostability has been an obstacle to global vaccination programs. To address this major limitation, we utilized carbohydrate-based ice recrystallization inhibitors (IRIs) to eliminate the cold chain and stabilize the potency of Vaccinia virus (VV), Vesicular Stomatitis virus (VSV) and Herpes virus-1 (HSV-1). The impact of these IRIs was tested on the potency of the viral vectors using a plaque forming unit assay following room temperature storage ...[more]