Ontology highlight
ABSTRACT:
SUBMITTER: Sirajuddin M
PROVIDER: S-EPMC4117587 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Sirajuddin Minhajuddin M Rice Luke M LM Vale Ronald D RD
Nature cell biology 20140316 4
The 'tubulin-code' hypothesis proposes that different tubulin genes or post-translational modifications (PTMs), which mainly confer variation in the carboxy-terminal tail (CTT), result in unique interactions with microtubule-associated proteins for specific cellular functions. However, the inability to isolate distinct and homogeneous tubulin species has hindered biochemical testing of this hypothesis. Here, we have engineered 25 α/β-tubulin heterodimers with distinct CTTs and PTMs and tested th ...[more]