Ontology highlight
ABSTRACT:
SUBMITTER: Kuroki H
PROVIDER: S-EPMC4118850 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kuroki Hideyuki H Hayashi Hiromitsu H Okabe Hirohisa H Hashimoto Daisuke D Takamori Hiroshi H Nakahara Osamu O Nakagawa Shigeki S Fukushima Yukiko Y Chikamoto Akira A Beppu Toru T Hirota Masahiko M Iyama Ken-ichi K Baba Hideo H
PloS one 20140801 8
<h4>Background</h4>The epigenetic mechanism of tumorigenesis in pancreatic intraductal papillary mucinous neoplasm (IPMN) remains largely unknown. The aim of this study is to examine the role of enhancer of zeste homologue 2 (EZH2) alteration in pancreatic IPMN progression.<h4>Methods</h4>Fifty-four surgically resected pancreatic IPMN specimens, including a total of 181 lesions (normal duct in 48, adenoma in 50, borderline atypia in 53, carcinoma in situ (CIS) in 19, and invasive carcinoma in 11 ...[more]