Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in men.
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ABSTRACT:
SUBMITTER: Guay SP
PROVIDER: S-EPMC4120725 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
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Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in men.
Guay Simon-Pierre SP Légaré Cécilia C Houde Andrée-Anne AA Mathieu Patrick P Bossé Yohan Y Bouchard Luigi L
Clinical epigenetics 20140729 1
<h4>Background</h4>Previous studies have suggested that DNA methylation contributes to coronary artery disease (CAD) risk variability. DNA hypermethylation at the ATP-binding cassette transporter A1 (ABCA1) gene, an important modulator of high-density lipoprotein cholesterol and reverse cholesterol transport, has been previously associated with plasma lipid levels, aging and CAD, but the association with CAD has yet to be replicated.<h4>Results</h4>ABCA1 DNA methylation levels were measured in l ...[more]
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