Ontology highlight
ABSTRACT:
SUBMITTER: Xiong X
PROVIDER: S-EPMC4120946 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Xiong Xiangyang X Wang Yao Y Liu Chengmei C Lu Quqin Q Liu Tao T Chen Guoan G Rao Hai H Luo Shiwen S
Experimental cell research 20140528 1
Focal adhesion kinase (FAK) acts as a regulator of cellular signaling and may promote cell spreading, motility, invasion and survival in malignancy. Elevated expression and activity of FAK frequently correlate with tumor cell metastasis and poor prognosis in breast cancer. However, the mechanisms by which the turnover of FAK is regulated remain elusive. Here we report that heat shock protein 90β (HSP90β) interacts with FAK and the middle domain (amino acids 233-620) of HSP90β is mainly responsib ...[more]