Ontology highlight
ABSTRACT:
SUBMITTER: Huang ML
PROVIDER: S-EPMC4121001 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20140717 30
Growth factor (GF) signaling is a key determinant of stem cell fate. Interactions of GFs with their receptors are often mediated by heparan sulfate proteoglycans (HSPGs). Here, we report a cell surface engineering strategy that exploits the function of HSPGs to promote differentiation in embryonic stem cells (ESCs). We have generated synthetic neoproteoglycans (neoPGs) with affinity for the fibroblast growth factor 2 (FGF2) and introduced them into plasma membranes of ESCs deficient in HS biosyn ...[more]