Ontology highlight
ABSTRACT:
SUBMITTER: Umschweif G
PROVIDER: S-EPMC4121449 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Umschweif Gali G Liraz-Zaltsman Sigal S Shabashov Dalia D Alexandrovich Alexander A Trembovler Victoria V Horowitz Michal M Shohami Esther E
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20140701 3
Angiotensin II receptor type 2 (AT(2)) agonists have been shown to limit brain ischemic insult and to improve its outcome. The activation of AT(2) was also linked to induced neuronal proliferation and differentiation in vitro. In this study, we examined the therapeutic potential of AT(2) activation following traumatic brain injury (TBI) in mice, a brain pathology that displays ischemia-like secondary damages. The AT(2) agonist CGP42112A was continuously infused immediately after closed head inju ...[more]