Ontology highlight
ABSTRACT:
SUBMITTER: Harman AN
PROVIDER: S-EPMC4123420 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Harman Andrew N AN Lai Joey J Turville Stuart S Samarajiwa Shamith S Gray Lachlan L Marsden Valerie V Mercier Sarah K SK Jones Kate K Nasr Najla N Rustagi Arjun A Cumming Helen H Donaghy Heather H Mak Johnson J Gale Michael M Churchill Melissa M Hertzog Paul P Cunningham Anthony L AL
Blood 20110316 2
Many viruses have developed mechanisms to evade the IFN response. Here, HIV-1 was shown to induce a distinct subset of IFN-stimulated genes (ISGs) in monocyte-derived dendritic cells (DCs), without detectable type I or II IFN. These ISGs all contained an IFN regulatory factor 1 (IRF-1) binding site in their promoters, and their expression was shown to be driven by IRF-1, indicating this subset was induced directly by viral infection by IRF-1. IRF-1 and -7 protein expression was enriched in HIV p ...[more]