Ontology highlight
ABSTRACT:
SUBMITTER: Weidlich IE
PROVIDER: S-EPMC4123439 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Weidlich Iwona E IE Dexheimer Thomas T Marchand Christophe C Antony Smitha S Pommier Yves Y Nicklaus Marc C MC
Bioorganic & medicinal chemistry 20091111 1
Human tyrosyl-DNA phosphodiesterase (hTdp1) inhibitors have become a major area of drug research and structure-based design since they have been shown to work synergistically with camptothecin (CPT) and selectively in cancer cells. The pharmacophore features of 14 hTdp1 inhibitors were used as a filter to screen the ChemNavigator iResearch Library of about 27 million purchasable samples. Docking of the inhibitors and hits obtained from virtual screening was performed into a structural model of h ...[more]