Ontology highlight
ABSTRACT:
SUBMITTER: Dorrance AM
PROVIDER: S-EPMC4126546 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
F1000prime reports 20140801
Aldosterone is a potent mineralocorticoid produced by the adrenal gland. Aldosterone binds to and activates the mineralocorticoid receptor (MR) in a plethora of tissues, but the cardiovascular actions of aldosterone are of primary interest clinically. Although MR antagonists were developed as antihypertensive agents, they are now considered to be important therapeutic options for patients with heart failure. Specifically, blocking only the MR has proven to be a difficult task because of its simi ...[more]