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Pressure-voltage trap for DNA near a solid-state nanopore.

ABSTRACT: We report the formation of a tunable single DNA molecule trap near a solid-state nanopore in an electrolyte solution under conditions where an electric force and a pressure-induced viscous flow force on the molecule are nearly balanced. Trapped molecules can enter the pore multiple times before escaping the trap by passing through the pore or by diffusing away. Statistical analysis of many individually trapped molecules yields a detailed picture of the fluctuation phenomena involved, which are successfully modeled by a one-dimensional first passage approach.

SUBMITTER: Hoogerheide DP

PROVIDER: S-EPMC4131299 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Pressure-voltage trap for DNA near a solid-state nanopore.

Hoogerheide David P DP Lu Bo B Golovchenko Jene A JA

ACS nano 20140620 7

We report the formation of a tunable single DNA molecule trap near a solid-state nanopore in an electrolyte solution under conditions where an electric force and a pressure-induced viscous flow force on the molecule are nearly balanced. Trapped molecules can enter the pore multiple times before escaping the trap by passing through the pore or by diffusing away. Statistical analysis of many individually trapped molecules yields a detailed picture of the fluctuation phenomena involved, which are s ...[more]

PMID: 24933128

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