Interchromosomal communication coordinates intrinsically stochastic expression between alleles.
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ABSTRACT:
SUBMITTER: Johnston RJ
PROVIDER: S-EPMC4134473 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Interchromosomal communication coordinates intrinsically stochastic expression between alleles.
Johnston Robert J RJ Desplan Claude C
Science (New York, N.Y.) 20140201 6171
Sensory systems use stochastic mechanisms to diversify neuronal subtypes. In the Drosophila eye, stochastic expression of the PAS-bHLH transcription factor Spineless (Ss) determines a random binary subtype choice in R7 photoreceptors. Here, we show that a stochastic, cell-autonomous decision to express ss is made intrinsically by each ss locus. Stochastic on or off expression of each ss allele is determined by combinatorial inputs from one enhancer and two silencers acting at long range. However ...[more]
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