Ontology highlight
ABSTRACT:
SUBMITTER: Sun H
PROVIDER: S-EPMC4135591 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Sun Huaiyu H Liu Yijing Y Hunter Tony T
Molecular and cellular biology 20140609 16
The RING domain protein Arkadia/RNF111 is a ubiquitin ligase in the transforming growth factor β (TGFβ) pathway. We previously identified Arkadia as a small ubiquitin-like modifier (SUMO)-binding protein with clustered SUMO-interacting motifs (SIMs) that together form a SUMO-binding domain (SBD). However, precisely how SUMO interaction contributes to the function of Arkadia was not resolved. Through analytical molecular and cell biology, we found that the SIMs share redundant function with Arkad ...[more]