Ontology highlight
ABSTRACT:
SUBMITTER: Kang YJ
PROVIDER: S-EPMC4137325 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Kang Yoon Joong YJ Zeng Wanyong W Song Weihua W Reinhold Bruce B Choi Jaewon J Brusic Vladimir V Yamashita Takuto T Munshi Aditya A Li Cheng C Minvielle Stephane S Anderson Kenneth C KC Munshi Nikhil N Reinherz Ellis L EL Sasada Tetsuro T
British journal of haematology 20130830 3
Despite the recent development of effective therapeutic agents against multiple myeloma (MM), new therapeutic approaches, including immunotherapies, remain to be developed. Here we identified novel human leucocyte antigen (HLA)-A*0201 (HLA-A2)-restricted cytotoxic T lymphocyte (CTL) epitopes from a B cell specific molecule HLA-DOβ (DOB) as a potential target for MM. By DNA microarray analysis, the HLA-DOB expression in MM cells was significantly higher than that in normal plasma cells. Twenty-fi ...[more]