Dataset Information

Diabetes mellitus as a risk factor for open-angle glaucoma: a systematic review and meta-analysis.

ABSTRACT:

Objective

To determine the association between diabetes mellitus (DM) and primary open-angle glaucoma (POAG).

Methods

This is a systematic review and meta-analysis of case-control and cohort studies. The literature search included two databases (PubMed and Embase) and the reference lists of the retrieved studies. Separate meta-analyses for case-control studies and cohort studies were conducted using random-effects models, with results reported as adjusted odds ratios (ORs) and relative risks (RRs), respectively.

Results

Thirteen studies--seven case-control studies and six population-based cohort studies--were included in this meta-analysis. The pooled RR of the association between DM and POAG based on the risk estimates of the six cohort studies was 1.40 (95% CI, 1.25-1.57). The pooled OR of the association between DM and POAG based on the risk estimates of the seven case-control studies was 1.49 (95% CI, 1.17-1.88). There was considerable heterogeneity among the case-control studies that reported an association between DM mellitus and POAG (P<0.001) and no significant heterogeneity among the cohort studies (P?=?0.377). After omitting the case-control study that contributed significantly to the heterogeneity, the pooled OR for the association between DM and POAG was 1.35 (95% CI, 1.06-1.74).

Conclusions

Individuals with DM have an increased risk of developing POAG.

SUBMITTER: Zhou M

PROVIDER: S-EPMC4138056 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Diabetes mellitus as a risk factor for open-angle glaucoma: a systematic review and meta-analysis.

Zhou Minwen M Wang Wei W Huang Wenbin W Zhang Xiulan X

PloS one 20140819 8

<h4>Objective</h4>To determine the association between diabetes mellitus (DM) and primary open-angle glaucoma (POAG).<h4>Methods</h4>This is a systematic review and meta-analysis of case-control and cohort studies. The literature search included two databases (PubMed and Embase) and the reference lists of the retrieved studies. Separate meta-analyses for case-control studies and cohort studies were conducted using random-effects models, with results reported as adjusted odds ratios (ORs) and rel ...[more]

PMID: 25137059

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Dataset Information

Diabetes mellitus as a risk factor for open-angle glaucoma: a systematic review and meta-analysis.

Objective

Methods

Results

Conclusions

Publications

Diabetes mellitus as a risk factor for open-angle glaucoma: a systematic review and meta-analysis.

Similar Datasets

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