Dataset Information

Systemic hypertension as a risk factor for open-angle glaucoma: a meta-analysis of population-based studies.

ABSTRACT:

Background/aims

Systemic hypertension is thought to increase the risk for developing open-angle glaucoma (OAG) through several mechanisms. However, previous epidemiological studies have shown conflicting results regarding this potential association. We systematically evaluated this issue by conducting a meta-analysis of population-based studies.

Methods

A comprehensive search for articles published before 31 March 2014 was performed using PubMed, Embase, and reference lists. The pooled odds ratio (OR) was calculated using the fixed- and random-effects models, and meta-regression was performed according to age. Subgroup analyses were also conducted, and publication bias was assessed using a funnel plot and Egger's regression test.

Results

This meta-analysis included 16 studies involving 60,084 individuals, with substantial homogeneity among the studies. The pooled OR for OAG was 1.22 (95% confidence interval, CI: 1.09-1.36) using the fixed-effects model and 1.22 (95% CI: 1.08-1.37) using the random-effects model in all included studies. For subgroup analyses, the pooled OR for high-tension glaucoma (HTG) was higher than that for normal-tension glaucoma (NTG) (OR=1.92 and 0.94, respectively). No significant difference was detected between Asian and Western populations, and no publication bias was detected in either analysis.

Conclusions

Systemic hypertension increases the risk for developing OAG, especially in those with HTG.

SUBMITTER: Bae HW

PROVIDER: S-EPMC4177901 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Systemic hypertension as a risk factor for open-angle glaucoma: a meta-analysis of population-based studies.

Bae Hyoung Won HW Lee Naeun N Lee Hye Sun HS Hong Samin S Seong Gong Je GJ Kim Chan Yun CY

PloS one 20140925 9

<h4>Background/aims</h4>Systemic hypertension is thought to increase the risk for developing open-angle glaucoma (OAG) through several mechanisms. However, previous epidemiological studies have shown conflicting results regarding this potential association. We systematically evaluated this issue by conducting a meta-analysis of population-based studies.<h4>Methods</h4>A comprehensive search for articles published before 31 March 2014 was performed using PubMed, Embase, and reference lists. The p ...[more]

PMID: 25254373

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Project description:BACKGROUND:Both glaucoma and obstructive sleep apnea (OSA) are widespread diseases. OSA may presumably partly cause or worsen glaucoma, although the etiopathogenesis is unclear. Here we analyze for the first time the possible association between different glaucoma phenotypes and OSA. METHODS:110 patients (47 females, 63 males; median age 64.3?years, median BMI 26.62?kg/m2) with suspected glaucoma and without any prior diagnosis of OSA were prospectively studied by one-night home sleep apnea testing (HSAT), 101 of the patients were analyzed. HSAT parameters, like apnea hypopnea index (AHI) and oxygen desaturation index as well as opthalmological parameters like intraocular pressure (IOP) and mean defect depth (MD) were collected. Moreover, HSAT results were compared across four phenotypic groups: primary open angle glaucoma (POAG), low-tension-glaucoma (LTG), ocular hypertension (OH), and controls. RESULTS:There was no strong correlation between IOP or MD and AHI. BMI, age and gender did not differ between groups. Significant differences between POAG and LTG were found for all HSAT parameters. The AHI showed the most prominent group difference (Wilcoxon-Kruskal-Wallis rank sum test was highly significant with chi2?=?22, df?=?3 p?<?0.0001) with severely lower event rates in the LTG (9.45/h) compared to POAG (22.7/h) and controls (21.9/h; p?<?0.0001 and 0.02, respectively). Highly significant differences were found between the four groups regarding AHI (Chi2?=?22, df?=?3, p?<?0.0001) with significantly lower events per hour in the LTG compared to POAG (Hodges-Lehmann?=?-?13.8, 95% CI (-?18.6 - -?8.8; p?<?0.0001) and to controls (Hodges-Lehmann?=?12.1, 95% CI -19.9 - -?2.4; p?<?0.02). Severe and moderate OSA was more prevalent in POAG (69.8%) and OH (33.3%) than in LTG (9%). The effect of the glaucoma phenotype on the AHI was more prominent in females (p?=?0.0006) than in males (p?=?0.011). CONCLUSION:Although physical endpoints, such as MD and IOP, do not correlate with AHI, there was a strong correlation between the POAG and OH clinical glaucoma phenotypes and the AHI. Further studies should investigate the necessity to test routine screening for OSA by HSAT in patients with diagnosed POAG and OH. Besides, some characteristics of LTG differed widely from other glaucoma types and controls. LTG patients had a significantly lower rate of OSA compared to other glaucoma types and even controls. This might be due to a different pathogenesis of LTG. TRIAL REGISTRATION:Retrospectively registered at DRKS ( nr. S00021201 ) on April 9th 2020.

Dataset Information

Systemic hypertension as a risk factor for open-angle glaucoma: a meta-analysis of population-based studies.

Background/aims

Methods

Results

Conclusions

Publications

Systemic hypertension as a risk factor for open-angle glaucoma: a meta-analysis of population-based studies.

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