Ontology highlight
ABSTRACT:
SUBMITTER: Rouya C
PROVIDER: S-EPMC4138323 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Rouya Christopher C Siddiqui Nadeem N Morita Masahiro M Duchaine Thomas F TF Fabian Marc R MR Sonenberg Nahum N
RNA (New York, N.Y.) 20140717 9
MicroRNAs (miRNAs) play critical roles in a variety of biological processes through widespread effects on protein synthesis. Upon association with the miRNA-induced silencing complex (miRISC), miRNAs repress target mRNA translation and accelerate mRNA decay. Degradation of the mRNA is initiated by shortening of the poly(A) tail by the CCR4-NOT deadenylase complex followed by the removal of the 5' cap structure and exonucleolytic decay of the mRNA. Here, we report a direct interaction between the ...[more]