Ontology highlight
ABSTRACT:
SUBMITTER: Lamberti G
PROVIDER: S-EPMC4139165 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Lamberti Giuseppina G Prabhakarpandian Balabhaskar B Garson Charles C Smith Ashley A Pant Kapil K Wang Bin B Kiani Mohammad F MF
Analytical chemistry 20140805 16
Current in vitro models of the leukocyte adhesion cascade cannot be used for real-time studies of the entire leukocyte adhesion cascade, including rolling, adhesion, and migration in a single assay. In this study, we have developed and validated a novel bioinspired microfluidic assay (bMFA) and used it to test the hypothesis that blocking of specific steps in the adhesion/migration cascade significantly affects other steps of the cascade. The bMFA consists of an endothelialized microvascular net ...[more]