Ontology highlight
ABSTRACT:
SUBMITTER: Ye D
PROVIDER: S-EPMC4140571 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Ye Deju D Pandit Prachi P Kempen Paul P Lin Jianguo J Xiong Liqin L Sinclair Robert R Rutt Brian B Rao Jianghong J
Bioconjugate chemistry 20140721 8
Controlled self-assembly of small molecule gadolinium (Gd) complexes into nanoparticles (GdNPs) is emerging as an effective approach to design activatable magnetic resonance imaging (MRI) probes and amplify the r₁ relaxivity. Herein, we employ a reduction-controlled macrocyclization reaction and self-assembly to develop a redox activated Gd-based MRI probe for sensing a reducing environment. Upon disulfide reduction at physiological conditions, an acyclic contrast agent 1 containing dual Gd-chel ...[more]