Ontology highlight
ABSTRACT:
SUBMITTER: Lin X
PROVIDER: S-EPMC4143043 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Lin Xingcheng X Eddy Nathanial R NR Noel Jeffrey K JK Whitford Paul C PC Wang Qinghua Q Ma Jianpeng J Onuchic José N JN
Proceedings of the National Academy of Sciences of the United States of America 20140731 33
Influenza hemagglutinin (HA), a homotrimeric glycoprotein crucial for membrane fusion, undergoes a large-scale structural rearrangement during viral invasion. X-ray crystallography has shown that the pre- and postfusion configurations of HA2, the membrane-fusion subunit of HA, have disparate secondary, tertiary, and quaternary structures, where some regions are displaced by more than 100 Å. To explore structural dynamics during the conformational transition, we studied simulations of a minimally ...[more]