Ontology highlight
ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC4143708 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
BMC proceedings 20140617 Suppl 1
We apply a family-based extension of the sequence kernel association test (SKAT) to 93 trios extracted from the 20 pedigrees in the Genetic Analysis Workshop 18 simulated data. Each extracted trio includes a unique set of parents to ensure conditionally independent trios are sampled. We compare the empirical type I error and power between the family-based SKAT and the burden test under varying percentages of causal single-nucleotide polymorphisms included in the analysis. Our investigation using ...[more]