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Pd-porphyrin-cross-linked implantable hydrogels with oxygen-responsive phosphorescence.


ABSTRACT: Development of long-term implantable luminescent biosensors for subcutaneous oxygen has proved challenging due to difficulties in immobilizing a biocompatible matrix that prevents sensor aggregation yet maintains sufficient concentration for transdermal optical detection. Here, Pd-porphyrins can be used as PEG cross-linkers to generate a polyamide hydrogel with extreme porphyrin density (?5 × 10(-3) m). Dye aggregation is avoided due to the spatially constraining 3D mesh formed by the porphyrins themselves. The hydrogel exhibits oxygen-responsive phosphorescence and can be stably implanted subcutaneously in mice for weeks without degradation, bleaching, or host rejection. To further facilitate oxygen detection using steady-state techniques, an oxygen-non-responsive companion hydrogel is developed by blending copper and free base porphyrins to yield intensity-matched luminescence for ratiometric detection.

SUBMITTER: Huang H 

PROVIDER: S-EPMC4143977 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Pd-porphyrin-cross-linked implantable hydrogels with oxygen-responsive phosphorescence.

Huang Haoyuan H   Song Wentao W   Chen Guanying G   Reynard Justin M JM   Ohulchanskyy Tymish Y TY   Prasad Paras N PN   Bright Frank V FV   Lovell Jonathan F JF  

Advanced healthcare materials 20131120 6


Development of long-term implantable luminescent biosensors for subcutaneous oxygen has proved challenging due to difficulties in immobilizing a biocompatible matrix that prevents sensor aggregation yet maintains sufficient concentration for transdermal optical detection. Here, Pd-porphyrins can be used as PEG cross-linkers to generate a polyamide hydrogel with extreme porphyrin density (≈5 × 10(-3) m). Dye aggregation is avoided due to the spatially constraining 3D mesh formed by the porphyrins  ...[more]

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