Ontology highlight
ABSTRACT:
SUBMITTER: Sage DP
PROVIDER: S-EPMC4145254 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Sage Daniel P DP Kulczar Christopher C Roth Wyatt W Liu Wanqing W Knipp Gregory T GT
Frontiers in genetics 20140827
The development of new therapeutic agents for the mitigation of pediatric disorders is largely hindered by the inability for investigators to assess pediatric pharmacokinetics (PK) in healthy patients due to substantial safety concerns. Pediatric patients are a clinical moving target for drug delivery due to changes in absorption, distribution, metabolism and excretion (ADME) and the potential for PK related toxicological (T) events to occur throughout development. These changes in ADMET can hav ...[more]