Ontology highlight
ABSTRACT:
SUBMITTER: Kosla K
PROVIDER: S-EPMC4148378 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Kośla Katarzyna K Nowakowska Magdalena M Pospiech Karolina K Bednarek Andrzej K AK
Oncology reports 20140717 4
The aim of the present study was to assess the influence of WWOX gene upregulation on the transcriptome and phenotype of the T98G glioblastoma cell line. The cells with high WWOX expression demonstrated a significantly different transcription profile for approximately 3,000 genes. The main cellular pathways affected were Wnt, TGFβ, Notch and Hedgehog. Moreover, the WWOX-transfected cells proliferated at less than half the rate, exhibited greatly lowered adhesion to ECM, increased apoptosis and i ...[more]