Ontology highlight
ABSTRACT:
SUBMITTER: Yuan AH
PROVIDER: S-EPMC4150125 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Yuan Andy H AH Garrity Sean J SJ Nako Entela E Hochschild Ann A
eLife 20140813
Prions are self-propagating protein aggregates that are characteristically transmissible. In mammals, the PrP protein can form a prion that causes the fatal transmissible spongiform encephalopathies. Prions have also been uncovered in fungi, where they act as heritable, protein-based genetic elements. We previously showed that the yeast prion protein Sup35 can access the prion conformation in Escherichia coli. Here, we demonstrate that E. coli can propagate the Sup35 prion under conditions that ...[more]