Ontology highlight
ABSTRACT:
SUBMITTER: Park KW
PROVIDER: S-EPMC5363067 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Park Kyung-Won KW Eun Kim Gyoung G Morales Rodrigo R Moda Fabio F Moreno-Gonzalez Ines I Concha-Marambio Luis L Lee Amy S AS Hetz Claudio C Soto Claudio C
Scientific reports 20170323
Prion diseases are fatal neurodegenerative disorders affecting several mammalian species, characterized by the accumulation of the misfolded form of the prion protein, which is followed by the induction of endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR). GRP78, also called BiP, is a master regulator of the UPR, reducing ER stress levels and apoptosis due to an enhancement of the cellular folding capacity. Here, we studied the role of GRP78 in prion dis ...[more]