Ontology highlight
ABSTRACT:
SUBMITTER: Weymouth N
PROVIDER: S-EPMC4151467 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Weymouth Nate N Shi Zengdun Z Rockey Don C DC
Developmental biology 20111112 1
Smooth muscle α-actin (Acta2) is one of six highly conserved mammalian actin isoforms that appear to exhibit functional redundancy. Nonetheless, we have postulated a specific functional role for the smooth muscle specific isoform. Here, we show that Acta2 deficient mice have a remarkable mammary phenotype such that dams lacking Acta2 are unable to nurse their offspring effectively. The phenotype was rescued in cross fostering experiments with wild type mice, excluding a developmental defect in A ...[more]