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Correlates and reference limits of plasma gamma-glutamyltransferase fractions from the Framingham Heart Study.


ABSTRACT: We assessed GGT fractions correlates and their reference values in the Offspring Cohort of the Framingham Heart Study.Correlates of GGT fractions were assessed by multivariable regression analysis in 3203 individuals [47% men, mean age (SD): 59 (10) years]. GGT fractions reference values were established by empirical quantile analysis in a reference group of 432 healthy subjects [45% men, 57 (10) years].Fractional GGT levels were higher in men than in women (P<0.0001). In both sexes, fractions were associated with: triglycerides were associated with b-GGT, alcohol consumption with m-, s- and f-GGT. C-reactive protein with m- and s-GGT, while plasminogen activator inhibitor-1 with b- and f-GGT. Body mass index, blood pressure, glucose and triglycerides correlated with b- and f-GGT. In comparison with the reference group [b-GGT/s-GGT median (Q1-Q3): 0.51 (0.35-0.79)U/L], subjects affected by cardiovascular disease or diabetes showed no change of b/s ratio [0.52 (0.34-0.79)U/L, 0.57 (0.40-0.83)U/L, respectively]. The b/s ratio was higher in presence of metabolic syndrome [0.61 (0.42-0.87)U/L, P<0.0001], while lower in heavy alcohol consumers [0.41 (0.28-0.64)U/L, P<0.0001].Metabolic and cardiovascular risk markers are important correlates of GGT fractions, in particular of b-GGT.

SUBMITTER: Franzini M 

PROVIDER: S-EPMC4154585 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Correlates and reference limits of plasma gamma-glutamyltransferase fractions from the Framingham Heart Study.

Franzini Maria M   Fornaciari Irene I   Rong Jian J   Larson Martin G MG   Passino Claudio C   Emdin Michele M   Paolicchi Aldo A   Vasan Ramachandran S RS  

Clinica chimica acta; international journal of clinical chemistry 20121214


<h4>Background</h4>We assessed GGT fractions correlates and their reference values in the Offspring Cohort of the Framingham Heart Study.<h4>Methods</h4>Correlates of GGT fractions were assessed by multivariable regression analysis in 3203 individuals [47% men, mean age (SD): 59 (10) years]. GGT fractions reference values were established by empirical quantile analysis in a reference group of 432 healthy subjects [45% men, 57 (10) years].<h4>Results</h4>Fractional GGT levels were higher in men t  ...[more]

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