Ontology highlight
ABSTRACT:
SUBMITTER: Bielig H
PROVIDER: S-EPMC4154870 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
PLoS pathogens 20140904 9
NOD1 is an intracellular pathogen recognition receptor that contributes to anti-bacterial innate immune responses, adaptive immunity and tissue homeostasis. NOD1-induced signaling relies on actin remodeling, however, the details of the connection of NOD1 and the actin cytoskeleton remained elusive. Here, we identified in a druggable-genome wide siRNA screen the cofilin phosphatase SSH1 as a specific and essential component of the NOD1 pathway. We show that depletion of SSH1 impaired pathogen ind ...[more]