Ontology highlight
ABSTRACT:
SUBMITTER: Hauser JL
PROVIDER: S-EPMC4157180 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Hauser Jessica L JL Liu Xiaojin X Litvina Elizabeth Y EY Chen Chinfei C
Journal of neurophysiology 20140625 7
The retinogeniculate synapse, the connection between retinal ganglion cells (RGC) and thalamic relay neurons, undergoes robust changes in connectivity over development. This process of synapse elimination and strengthening of remaining inputs is thought to require synapse specificity. Here we show that glutamate spillover and asynchronous release are prominent features of retinogeniculate synaptic transmission during this period. The immature excitatory postsynaptic currents exhibit a slow decay ...[more]