Ontology highlight
ABSTRACT:
SUBMITTER: Wolf AI
PROVIDER: S-EPMC4157663 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Wolf Amaya I AI Strauman Maura C MC Mozdzanowska Krystyna K Williams Katie L KL Osborne Lisa C LC Shen Hao H Liu Qin Q Garlick David D Artis David D Hensley Scott E SE Caton Andrew J AJ Weiser Jeffrey N JN Erikson Jan J
Virology 20140705
The response to influenza virus (IAV) infection and severity of disease is highly variable in humans. We hypothesized that one factor contributing to this variability is the presence of specific respiratory tract (RT) microbes. One such microbe is Streptococcus pneumoniae (Sp) that is carried asymptomatically in the RT of many humans. In a mouse co-infection model we found that in contrast to secondary bacterial infection that exacerbates disease, Sp colonization 10 days prior to IAV protects fr ...[more]