Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen CT
PROVIDER: S-EPMC4314132 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Molecules and cells 20141216 1
Activating transcription factor-3 (ATF3) acts as a negative regulator of cytokine production during Gram-negative bacterial infection. A recent study reported that ATF3 provides protection from Streptococcus pneumoniae infection by activating cytokines. However, the mechanism by which S. pneumoniae induces ATF3 after infection is still unknown. In this study, we show that ATF3 was upregulated via Toll-like receptor (TLR) pathways in response to S. pneumoniae infection in vitro. Induction was med ...[more]