Ontology highlight
ABSTRACT:
SUBMITTER: Williams SE
PROVIDER: S-EPMC4159251 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Williams Scott E SE Ratliff Lyndsay A LA Postiglione Maria Pia MP Knoblich Juergen A JA Fuchs Elaine E
Nature cell biology 20140713 8
Asymmetric cell divisions allow stem cells to balance proliferation and differentiation. During embryogenesis, murine epidermis expands rapidly from a single layer of unspecified basal layer progenitors to a stratified, differentiated epithelium. Morphogenesis involves perpendicular (asymmetric) divisions and the spindle orientation protein LGN, but little is known about how the apical localization of LGN is regulated. Here, we combine conventional genetics and lentiviral-mediated in vivo RNAi t ...[more]