Ontology highlight
ABSTRACT:
SUBMITTER: Chang CW
PROVIDER: S-EPMC4160325 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Chang Chien-Wen CW Hwang Yongsung Y Brafman Dave D Hagan Thomas T Phung Catherine C Varghese Shyni S
Biomaterials 20121103 4
Cost-effective and scalable synthetic matrices that support long-term expansion of human pluripotent stem cells (hPSCs) have many applications, ranging from drug screening platforms to regenerative medicine. Here, we report the development of a hydrogel-based matrix containing synthetic heparin-mimicking moieties that supports the long-term expansion of hPSCs (≥20 passages) in a chemically defined medium. HPSCs expanded on this synthetic matrix maintained their characteristic morphology, colony ...[more]