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Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors.

ABSTRACT: Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure-activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties.

SUBMITTER: Subramanian S

PROVIDER: S-EPMC4160747 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors.

Subramanian Sharadha S Costales Abran A Williams Teresa E TE Levine Barry B McBride Christopher M CM Poon Daniel D Amiri Payman P Renhowe Paul A PA Shafer Cynthia M CM Stuart Darrin D Verhagen Joelle J Ramurthy Savithri S

ACS medicinal chemistry letters 20140717 9

Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure-activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties. ...[more]

PMID: 25221654

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