Ontology highlight
ABSTRACT:
SUBMITTER: Buisson R
PROVIDER: S-EPMC4162405 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Buisson Rémi R Niraj Joshi J Pauty Joris J Maity Ranjan R Zhao Weixing W Coulombe Yan Y Sung Patrick P Masson Jean-Yves JY
Cell reports 20140130 3
One envisioned function of homologous recombination (HR) is to find a template for DNA synthesis from the resected 3'-OH molecules that occur during double-strand break (DSB) repair at collapsed replication forks. However, the interplay between DNA synthesis and HR remains poorly understood in higher eukaryotic cells. Here, we reveal functions for the breast cancer proteins BRCA2 and PALB2 at blocked replication forks and show a role for these proteins in stimulating polymerase η (Polη) to initi ...[more]