Ontology highlight
ABSTRACT:
SUBMITTER: Mettrick KA
PROVIDER: S-EPMC4737137 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Mettrick Karla A KA Grainge Ian I
Nucleic acids research 20151020 2
Replication of chromosomal DNA must be carried out to completion in order for a cell to proliferate. However, replication forks can stall during this process for a variety of reasons, including nucleoprotein 'roadblocks' and DNA lesions. In these circumstances the replisome copying the DNA may disengage from the chromosome to allow various repair processes to restore DNA integrity and enable replication to continue. Here, we report the in vivo stability of the replication fork when it encounters ...[more]