Ontology highlight
ABSTRACT:
SUBMITTER: Ait-Saada A
PROVIDER: S-EPMC6771652 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Ait-Saada Anissia A Khorosjutina Olga O Chen Jiang J Kramarz Karol K Maksimov Vladimir V Svensson J Peter JP Lambert Sarah S Ekwall Karl K
Life science alliance 20191001 5
Here, we investigate the function of fission yeast Fun30/Smarcad1 family of SNF2 ATPase-dependent chromatin remodeling enzymes in DNA damage repair. There are three Fun30 homologues in fission yeast, Fft1, Fft2, and Fft3. We find that only Fft3 has a function in DNA repair and it is needed for single-strand annealing of an induced double-strand break. Furthermore, we use an inducible replication fork barrier system to show that Fft3 has two distinct roles at blocked DNA replication forks. First, ...[more]