Ontology highlight
ABSTRACT:
SUBMITTER: Christov PP
PROVIDER: S-EPMC4164228 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Chemical research in toxicology 20140828 9
N(5)-Substituted formamidopyrimidine adducts have been observed from the reaction of dGuo or DNA with aziridine containing electrophiles, including nitrogen mustards. However, the role of substituted Fapy-dGuo adducts in the biological response to nitrogen mustards and related species has not been extensively explored. We have developed chemistry for the site-specific synthesis of oligonucleotides containing an N(5)-nitrogen mustard Fapy-dGuo using the phosphoramidite approach. The lesion was fo ...[more]