Ontology highlight
ABSTRACT:
SUBMITTER: Saito K
PROVIDER: S-EPMC4164946 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
The Journal of cell biology 20140908 6
Mechanisms for exporting variably sized cargo from the endoplasmic reticulum (ER) using the same machinery remain poorly understood. COPII-coated vesicles, which transport secretory proteins from the ER to the Golgi apparatus, are typically 60-90 nm in diameter. However, collagen, which forms a trimeric structure that is too large to be accommodated by conventional transport vesicles, is also known to be secreted via a COPII-dependent process. In this paper, we show that Sec12, a guanine-nucleot ...[more]