MBASED: allele-specific expression detection in cancer tissues and cell lines.
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ABSTRACT:
SUBMITTER: Mayba O
PROVIDER: S-EPMC4165366 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
MBASED: allele-specific expression detection in cancer tissues and cell lines.
Mayba Oleg O Gilbert Houston N HN Liu Jinfeng J Haverty Peter M PM Jhunjhunwala Suchit S Jiang Zhaoshi Z Watanabe Colin C Zhang Zemin Z
Genome biology 20140807 8
Allele-specific gene expression, ASE, is an important aspect of gene regulation. We developed a novel method MBASED, meta-analysis based allele-specific expression detection for ASE detection using RNA-seq data that aggregates information across multiple single nucleotide variation loci to obtain a gene-level measure of ASE, even when prior phasing information is unavailable. MBASED is capable of one-sample and two-sample analyses and performs well in simulations. We applied MBASED to a panel of ...[more]
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