Pubertal onset in girls is strongly influenced by genetic variation affecting FSH action.
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ABSTRACT:
SUBMITTER: Hagen CP
PROVIDER: S-EPMC4166707 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Pubertal onset in girls is strongly influenced by genetic variation affecting FSH action.
Hagen Casper P CP Sørensen Kaspar K Aksglaede Lise L Mouritsen Annette A Mieritz Mikkel G MG Tinggaard Jeanette J Wohlfart-Veje Christine C Petersen Jørgen Holm JH Main Katharina M KM Rajpert-De Meyts Ewa E Almstrup Kristian K Juul Anders A
Scientific reports 20140918
Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-bas ...[more]
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