Ontology highlight
ABSTRACT:
SUBMITTER: Miller PS
PROVIDER: S-EPMC4167603 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Miller Paul S PS Aricescu A Radu AR
Nature 20140608 7514
Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers hyperactive neurological disorders such as insomnia, anxiety and epilepsy. Here we present the first three-dimensional structure of a GABAAR, the human β3 homopentamer, at 3 Å resolution. This structure reveals architectural elements unique to eukaryotic Cys-loop receptors, explains the mechanistic consequences of multipl ...[more]