Ontology highlight
ABSTRACT:
SUBMITTER: Waltenspuhl Y
PROVIDER: S-EPMC7439316 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Waltenspühl Yann Y Schöppe Jendrik J Ehrenmann Janosch J Kummer Lutz L Plückthun Andreas A
Science advances 20200715 29
The peptide hormone oxytocin modulates socioemotional behavior and sexual reproduction via the centrally expressed oxytocin receptor (OTR) across several species. Here, we report the crystal structure of human OTR in complex with retosiban, a nonpeptidic antagonist developed as an oral drug for the prevention of preterm labor. Our structure reveals insights into the detailed interactions between the G protein-coupled receptor (GPCR) and an OTR-selective antagonist. The observation of an extrahel ...[more]