Ontology highlight
ABSTRACT:
SUBMITTER: Ren Y
PROVIDER: S-EPMC4169672 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Ren Yue Y Dashtsoodol Nyambayar N Watarai Hiroshi H Koseki Haruhiko H Quan Chengshi C Taniguchi Masaru M
International immunology 20140522 10
NKT cells are characterized by their expression of an NKT-cell-specific invariant antigen-receptor α chain encoded by Vα14Jα18 gene segments. These NKT cells bridge the innate and acquired immune systems to mediate effective and augmented responses; however, the limited number of NKT cells in vivo hampers their analysis. Here, two lines of induced pluripotent stem cell-derived mice (NKT-iPSC-derived mice) were generated by reprogramming of mature NKT cells, where one harbors both rearranged Vα14 ...[more]