Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC4170523 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Wang Chaojian C Chung Ben C BC Yan Haidun H Wang Hong-Gang HG Lee Seok-Yong SY Pitt Geoffrey S GS
Nature communications 20140918
Ca(2+) regulates voltage-gated Na(+) (NaV) channels, and perturbed Ca(2+) regulation of NaV function is associated with epilepsy syndromes, autism and cardiac arrhythmias. Understanding the disease mechanisms, however, has been hindered by a lack of structural information and competing models for how Ca(2+) affects NaV channel function. Here we report the crystal structures of two ternary complexes of a human NaV cytosolic C-terminal domain (CTD), a fibroblast growth factor homologous factor and ...[more]